
程金波,教授,理学博士,硕士研究生导师,飞禽走兽
高层次优秀人才,美国Sanford-Burnham医学研究所访问学者。担任北京神经科学学会青年委员会副主任委员,中国卒中学会转化分会常务委员,Frontiers in Pharmacology副主编,Frontiers in Immunology等多项期刊责任主编,Journal of Neuroinflammation, Acta Pharmaceutica Sinica B, Cellular Signaling, Mitochondrion等期刊特邀审稿人。
一直从事神经精神疾病(阿尔茨海默病、帕金森氏病、抑郁症等)的致病机制与干预研究,重点关注小胶质细胞活化、神经炎症、表观遗传修饰等在疾病中的作用和机制,以第一作者或通讯作者在Science Advances(IF=14.9),Autophagy(IF=16.0), Cell Death and Differentiation(IF=15.8), Theranostics(IF=12.4), Protein & Cell(IF=15.3)等国际著名期刊发表SCI论文40多篇,被引用次数1000余次。合作研究工作发表在Cell Metabolism(IF=31.3),Science Advances(IF=14.9),Molecular Psychiatry(IF=13.4)等期刊。主持国家自然科学基金面上项目3项、青年基金项目1项、北京市自然基金面上项目1项、军队重大项目子课题2项,江西中医药大学开放课题1项等。已培养多名硕士研究生,博士研究生、博士后,获飞禽走兽
优秀硕士学位论文1项。
讲授课程:神经生物学、神经病理学、分子药理学、脑科学与脑健康、生物科学导论(生物医学部分)
通信地址:北京市海淀区中关村南大街27号 飞禽走兽
邮编:100081
电子邮箱: [email protected].
主要研究方向:
1. 神经退行性疾病的致病机制研究: Cell Death and Differentiation. 24.276-287. (IF: 15.8, SCI一区,第一作者)
5. Yuan Dong, Shuoshuo Li, Yiming Lu, Xiaoheng Li, Yajin Liao, Zhixin Peng, Yunfeng Li, Lin Hou*, Zengqiang Yuan*, Jinbo Cheng*. 2020. Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice. Journal of Neuroinflammation. 17.205 (IF: 9.5, SCI一区,通讯作者)
6. Yajin Liao#, Jinbo Cheng#, Xiangxi Kong#, , , , , , , , , Zengqiang Yuan*. 2020. HDAC3 inhibition ameliorates ischemia/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway. Theranostics. 2020 Jul 29;10(21):9644-9662. (IF:12.4, SCI一区,共第一作者)
7. Shuoshuo Li, Yajin Liao, Yuan Dong, Xiaoheng Li, Jun Li, Yong Cheng, Jinbo Cheng* and Zengqiang Yuan*. 2021. Microglial deletion and inhibition alleviate behavior of post-traumatic stress disorder in mice. Journal of Neuroinflammation. 18.7 (IF: 9.5, SCI一区,共通讯作者)
8. Cheng J*, Wang S, Dong Y and Yuan Z*. 2020. The Role and Regulatory Mechanism of Hippo Signaling Components in the Neuronal System. Front. Immunol. 11:281. doi: 10.3389/fimmu.2020.00281. (IF: 8.3,SCI二区,第一作者兼共通讯作者)
9. YanM, Bo X, Zhang X, Zhang J, Liao Y, Zhang H, Cheng Y, Guo J* and Cheng J*. 2022. Mangiferin Alleviates Postpartum Depression–Like Behaviors by Inhibiting MAPK Signaling in Microglia. Front. Pharmacol. 13:840567. (IF: 5.8,SCI二区,通讯作者)
10. Liao Y, Dong Y and Cheng J*. 2020. The Molecular Determinants of Mitochondrial Membrane Contact with ER, Lysosomes and Peroxisomes in Neuronal Physiology and Pathology. Front. Cell. Neurosci. 14:194. (IF: 5.5,SCI二区,通讯作者)
11. Xiaoheng Li, Yajin Liao, Yuan Dong, Shuoshuo Li, Fengchao Wang, Rong Wu, Zengqiang Yuan*, Jinbo Cheng* 2020. Mib2 Deficiency Inhibits Microglial Activation and Alleviates Ischemia-Induced Brain Injury. Aging and Disease. 11(3); 523-535. (IF: 6.7,SCI二区,通讯作者)
12. Yao R, Pan R, Shang C, Li X, Cheng J*, Xu J* and Li Y*. 2020. Translocator Protein 18 kDa (TSPO) Deficiency Inhibits Microglial Activation and Impairs Mitochondrial Function. Front. Pharmacol. 11:986. (IF: 5.8,SCI二区,共同通讯作者)
13. Kong X, Liao Y, Zhou L, Zhang Y, Cheng J*, Yuan Z* and Wang S*. 2020. Hematopoietic Cell Kinase (HCK) Is Essential for NLRP3 Inflammasome Activation and Lipopolysaccharide-Induced Inflammatory Response In Vivo. Front. Pharmacol. 11:581011. (IF: 5.8,SCI二区,共同通讯作者)
14. Lujun Zhou, Qiang Zhang, Peng Zhang, Zengqiang Yuan*, Jinbo Cheng* 2017. c-Abl-mediated Drp1 phosphorylation promotes oxidative stress-induced mitochondrial fragmentation and neuronal cell death. Cell Death and Disease. Oct 12;8(10):e3117 . (IF: 8.4,SCI二区, 通讯作者)
15. Jinbo Cheng, Yajin Liao, Lujun Zhou, Shengyi Peng, Hong Chen, Zengqiang Yuan. 2016. Amplified RLR signaling activation through an interferon-stimulated gene-endoplasmic reticulum stress-mitochondrial calcium uniporter protein loop. Scientific Reports. Feb 19; 6: 20158. (IF: 4.3,SCI二区,第一作者)
16. Yajin Liao, Yumin Hao, Hong Chen, Qing He, Zengqiang Yuan*, Jinbo Cheng*. 2015. Mitochondrial calcium uniporter protein MCU is involved in oxidative stress-induced cell death. Protein & Cell. 6, 434-442.(IF: 14.8,SCI二区, 通讯作者)
17. Yuan Dong, Xiaoheng Li, Jinbo Cheng*, Lin Hou*. 2019. Drug Development for Alzheimer’s Disease: Microglia Induced Neuroinflammation as a Target. International Journal of Molecular Sciences. Jan 28;20(3). pii: E558.(SCI三区, 共通讯作者)
18. Yajin Liao, Yuan Dong, Jinbo Cheng*. 2017. The Function of the Mitochondrial Calcium Uniporter in Neurodegenerative Disorders. International Journal of Molecular Sciences. 18. 248.(SCI三区, 通讯作者)
19. Xiangxi Kong, Zengqiang Yuan*, Jinbo Cheng*. 2016. The function of NOD-like receptors in central nervous system diseases. Journal of Neuroscience Research. 28. doi: 10.1002/jnr.24004.(SCI三区, 通讯作者)
20. Jinbo Cheng, Wei Tang, Zhenyi Su, Junxia Guo, Li Tong and Qun Wei. 2012. Calcineurin subunit B promotes TNF-ɑ-induced apoptosis by binding to mitochondria and causing mitochondrial Ca2+ overload. Cancer Letters. 321(2), 169-178. (IF: 8.6,SCI一区,第一作者)